Join us at the Asia Dengue Summit 2024!

Connect with Florence Herschke, PhD, our head of preclinical development, and Tessa Van Royen, one of our research scientists, next week at the 7th Asia Dengue Summit in Kuala Lumpur.

Exevir at ECCMID 2024

Our Chief Scientific Officer Viki Bockstal is presenting a poster at ECSMID Global 2024 (formerly known as ECCMID) from 27-30 April in vibrant Barcelona, the Mediterranean’s #lifesciences hub!

ExeVir Bio Appoints a Chief Scientific Officer

Ghent, Belgium, 1 September 2023: ExeVir Bio, a biotech company developing robust single-domain antibody therapies for broad protection against infectious diseases, today announced Dr. Viki Bockstal as its Chief Scientific Officer (CSO) and Caroline Sagaert as its Head of Operations. Jean-Philippe Bultot will become the Company’s Head of Finance and lead ExeVir’s finance and accounting. […]

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike

Currently circulating SARS-CoV-2 variants have gained complete or significant resistance to all SARSCoV-2-neutralizing antibodies that have been used in the clinic. Such antibodies can prevent severe disease in SARS-CoV-2 exposed patients for whom vaccines may not provide optimal protection. Here, we describe single-domain antibodies (VHHs), also known as nanobodies, that can broadly neutralize SARS-CoV-2 with unusually high potency. Structural analysis revealed their binding to a unique, highly conserved, membrane proximal, quaternary epitope in the S2 subunit of the spike. Furthermore, a VHH-human IgG1 Fc fusion, efficiently expressed in Chinese hamster ovary cells as a stable antibody construct, protected hamsters against SARS-CoV-2 replication in a therapeutic setting when administered systemically at low dose. This VHH-based antibody represents a new candidate anti-COVID-19 biologic that targets the Achilles heel of the viral spike.