Ghent, Belgium, 1 September 2023: ExeVir Bio, a biotech company developing robust single-domain antibody therapies for broad protection against infectious diseases, today announced Dr. Viki Bockstal as its Chief Scientific Officer (CSO) and Caroline Sagaert as its Head of Operations. Jean-Philippe Bultot will become the Company’s Head of Finance and lead ExeVir’s finance and accounting. […]
Dengue is a mosquito borne viral infection listed by WHO as top 10 threat for global health
The government grant is awarded by Flanders Innovation & Entrepreneurship (VLAIO)
Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike
Currently circulating SARS-CoV-2 variants have gained complete or significant resistance to all SARSCoV-2-neutralizing antibodies that have been used in the clinic. Such antibodies can prevent severe disease in SARS-CoV-2 exposed patients for whom vaccines may not provide optimal protection. Here, we describe single-domain antibodies (VHHs), also known as nanobodies, that can broadly neutralize SARS-CoV-2 with unusually high potency. Structural analysis revealed their binding to a unique, highly conserved, membrane proximal, quaternary epitope in the S2 subunit of the spike. Furthermore, a VHH-human IgG1 Fc fusion, efficiently expressed in Chinese hamster ovary cells as a stable antibody construct, protected hamsters against SARS-CoV-2 replication in a therapeutic setting when administered systemically at low dose. This VHH-based antibody represents a new candidate anti-COVID-19 biologic that targets the Achilles heel of the viral spike.
Excited to be a part of the Presenting Company Class of 2023 at BioEquity: Europe 2023!
ExeVir Bio and VIB-UGent’s bioRxiv pre-print reports on S2-binding camelid single-domain antibody-based drug, XVR013, that targets the Achilles’ heel in the SARS-CoV-2 viral spike
Focus on protecting the millions of immuno-compromised patients, who are most vulnerable to COVID-19
xeVir Bio, a biotech company developing robust nanobody therapies for broad protection against infectious diseases, today announced that it has secured a venture debt financing agreement of up to EUR 25M (around USD 26.5m) with the European Investment Bank (EIB)*. The EIB financing will help advance ExeVir’s lead asset, XVR012, into clinical trials for COVID-19.
ExeVir is a clinical-stage company developing novel antibody therapies that help patients ward off infectious diseases. Our focus is on protecting populations unable to benefit from vaccines, such as immunocompromised individuals. The versatile VHH platform enables both prevention and treatment of bacterial and viral threats.