ONE OF WHO's 2019 TOP 10 THREATS TO GLOBAL HEALTH *
390 million estimated infections globally **
20.000 to 25.000 deaths per year, primarily children ***
* World Health Organization, 2019, Ten threats to global health in 2019
** Ebi KL, 2016, Dengue in a changing climate
*** Schaeffer et al, 2022, Dengue fever
Dengue is the most important vector-borne viral disease globally that is transmitted from mosquitos to humans. Anyone living or traveling to endemic regions is at risk, corresponding to > 3.9 billion people globally. The disease is endemic in over 125 countries in (sub)tropical areas. Due to climate change, this region is expanding with outbreaks now happening in parts of mainland US and Europe. Travel and urbanization are other important factors increasing global incidence rates and outbreaks **.
There are four dengue virus serotypes, all of which can cause dengue fever or severe dengue, leading to hospitalization and death. The medical need remains very high as there are no specific antiviral therapeutics available yet for the disease, limiting the treatment options to relieving symptoms and preventing complications. The current vaccines protect against all four serotypes, but none are 100% effective. They also have limitations for use in immunocompromised and older people.
A compound with an innovative triple mode of action targeting all four dengue serotypes. It also shows potential for cross reactivity against other flaviviruses.